IGF-1 LR3

IGF-1 LR3 (Long R3 IGF-1) is an 83-amino-acid recombinant analog of insulin-like growth factor 1, engineered from the native IGF-1 sequence through two defining modifications: substitution of the glutamate residue at position 3 with arginine, and the addition of a 13-amino-acid N-terminal extension peptide. As a member of the insulin/IGF peptide superfamily, it retains the core structural motifs central to receptor-interaction studies while presenting altered affinity toward IGF-binding proteins relative to the native molecule. Pet & Peps Research supplies this analog as a lyophilized powder characterized at greater than or equal to 99% purity by HPLC, positioned as a defined reference standard for in-vitro and analytical laboratory work.

Within companion-animal research, IGF-1 LR3 is studied as a tool compound in models of growth-factor signaling and cell proliferation. Investigators employ it to probe the IGF-1 receptor axis and its associated downstream cascades in cultured cell systems, including canine and feline cell lines of research interest. Its close structural relationship to native IGF-1, paired with its distinct binding-protein behavior, makes it a recurring point of comparison in benchtop studies examining ligand-receptor interaction, binding-protein dynamics, and the regulation of proliferative signaling pathways under controlled laboratory conditions.

This product is characterized strictly as a laboratory reagent for benchtop and analytical applications such as receptor-binding assays, cell-culture signaling studies, and reference-standard comparison. It is offered for Research Use Only and is not intended for human or veterinary use, nor for any diagnostic, therapeutic, or in-vivo application. All descriptions herein refer to the compound's role as an investigational tool within study models and make no representation regarding physiological outcomes.